Marrow Failure Syndromes

Below you will find a collection of articles from Hematology, the ASH Education Program Book, written by experts in the field about current treatments for marrow failure syndromes, including myelodysplastic syndromes (MDS). This Web site also provides links to organizations that inform and support MDS patients and their families.

Acquired

Aplastic Anemia

• Aplastic Anemia: Pathogenesis and Treatment (2007)
• Pathophysiologic Mechanisms in Acquired Aplastic Anemia (2006)
• Making Therapeutic Decisions in Adults with Aplastic Anemia (2006)
  

Myelodysplastic Syndromes

• The Changing Classification of Myelodysplastic Syndromes: What’s In A Name? (2009)
• Treatment of MDS: Something Old, Something New, Something Borrowed... (2009)
• Supportive Care and Chelation Therapy In MDS: Are We Saving Lives Or Just Lowering Iron? (2009)
• Myelodysplastic Syndromes: An Historical Perspective (2008)
• MDS: A Stem Cell Disorder - But What Exactly Is Wrong with the Primitive Hematopoietic Cells in This Disease? (2008)
• The Role of JAK2 Mutations in RARS and Other MDS (2008)
• Epigenetic Modulation and Other Options to Improve Outcome of Stem Cell Transplanation in MDS (2008)
• Management of RBC-Transfusion Dependence (2007)
• Modifying the Epigenome as a Therapeutic Strategy in Myelodysplasia (2007)
• Genetic Pathways in the Pathogenesis of Therapy-Related Myelodysplasia and Acute Myeloid Leukemia (2007)
• Clinical Issues in the Management of Patients with Myelodysplasia (2006)
• Treatment of the 5q– Syndrome (2006)
  

Paroxysmal Nocturnal Hemoglobinuria

• Paroxysmal Nocturnal Hemoglobinuria (PNH): An Historical Perspective (2008)
• Paroxysmal Nocturnal Hemoglobinuria: An Historical Overview (2008)
• Which Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Should Be Treated with Eculizumab? (2008)
• The Pathophysiology of Disease in Patients with Paroxysmal Nocturnal Hemoglobinuria (2008)
• Paroxysmal Nocturnal Hemoglobinuria: Stem Cells and Clonality (2008)
• The Role of Complement Inhibition in PNH (2008)
• Coagulation in the Pathophysiology of Hemolytic Anemias (2007)

General

• Clinical Approach to Marrow Failure (2009)
• Telomeres and Marrow Failure (2009)
• Bone Marrow Failure as a Risk Factor for Clonal Evolution: Prospects for Leukemia Prevention (2007)
• Bone Marrow Failure: A Child Is Not Just a Small Adult (But an Adult Can Have a Childhood Disease) (2005)

Inherited

• Telomeres and Marrow Failure (2009)
• Congenital Neutropenia (2009)
• Diagnosis, Genetics, and Management of Inherited Bone Marrow Failure Syndromes (2007)

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